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October 09, 2008 -- 3:46 PM
posted by Beck
Is it the name Sonic hedgehog that's causing the wtf moment?
October 09, 2008 -- 11:26 AM
posted by Par
The patched/hedgehog intracellular signaling pathway plays a role in both sporadic [basal cell carcinomas] and in nevoid BCC syndrome (Gorlin syndrome). This pathway influences differentiation of a variety of tissues during fetal development. After embryogenesis, it continues to function in regulation of cell growth and differentiation. Loss of inhibition of this pathway is associated with human malignancy, including BCC.
The hedgehog gene encodes an extracellular protein that binds to a cell membrane receptor complex to start a cascade of cellular events leading to cell proliferation. Of the 3 known human homologs, Sonic hedgehog (SHH) protein is the most relevant to BCC.
October 08, 2008 -- 4:11 PM
posted by Dr. Riviera
Finally... a solution for opponents of abortion AND adoption!
http://www.cnn.com/2008/US/10/08/nebraska.safe.haven/index.html
October 08, 2008 -- 11:45 AM
posted by Par
Bad movie at Paras's house tonight. 8:30. Not sure if I can top Plan 9, but I can try...
October 07, 2008 -- 9:04 PM
posted by Jess
Best of Sarah Palin:
http://www.youtube.com/watch?v=NrzXLYA_e6E
October 07, 2008 -- 8:34 PM
posted by Par
Paras's uneducated guess as to the (unfortunate) moment of the debate: John McCain gesturing towards Barack Obama and referring to him as "that one." Yikes.
October 07, 2008 -- 8:17 PM
posted by Par
I've probably mentioned my fondness for The Big Picture before. This post is one of the best; photos from the "Earth From Above" exhibit:

October 07, 2008 -- 7:47 PM
posted by Al
In a morbid continuation of my earlier post:
A sign of the ongoing finacial troubles
Be warned this isn't a easy article to read or a easy video to see. A man left with no choice financially, decides that he has to kill his family and himself. It's rather sad so be warned.
October 07, 2008 -- 2:58 PM
posted by Beck
